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September 3, 2010
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Lecture Information

Duchenne Muscular Dystrophy: Natural History and Clinical Findings

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Slides:

  1. Muscular Dystrophy
  2. Duchenne/Becker Muscular Dystrophy
  3. Natural History of Duchenne Muscular Dystrophy
  4. Duchenne Muscular Dystrophy (Pseudohypertrophic MD)
  5. X-linked Recessive Inheritance
  6. DMD/BMD Gene
  7. Immunofluorescence Stain: Dystrophin
  8. Dystrophin
  9. Extracellular Matrix
  10. Muscular Dystrophy: Basic Concepts
  11. Normal Dystrophin-Glycoprotein Complex
  12. DMD Patients / Mdx Mouse
  13. Nature of the Injury – Proposed Mechanisms
  14. Mechanically Weakened Sarcolemma Hypothesis
  15. Mechanically Weakened Sarcolemma Hypothesis
  16. Mechanically Weakened Sarcolemma Hypothesis
  17. Simplified View of Pathophysiology in DMD
  18. Muscular Dystrophy – Muscle Biopsy Findings
  19. Muscle Biopsy: 3-yr-old, Normal
  20. Muscle Biopsy: 3-yr-old, DMD
  21. Muscle Biopsy: 9-yr-old, DMD
  22. Triceps Biopsy: 19-yr-old, DMD (Postmortem)
  23. Biceps Muscle (Gross Pathology): 19-yr-old, DMD (Postmortem)
  24. Gastrocnemius Muscle: 19-yr-old, DMD (Postmortem)
  25. Pattern of Weakness in DMD
  26. Graph
  27. Quantitative Strength Testing in DMD
  28. Isometric Strength Graph
  29. Classic Early Findings in DMD (Preschool and Early School Age)
  30. Gower's Sign
  31. Diagnostic Workup in DMD / BMD
  32. CK vs. Age (3 to 17 years)
  33. CK values may be 10-fold higher in younger patients with DMD
  34. Gait Adaptations

    Credit:

    RRTC/NMD Multimedia Training Project Manager: Kathryn Devereaux, PhD.
    Audio Editing: Jennifer Chang
    PowerPoint-Web Integration: Eli Richmond, Nhung Ngo.
    Technical Support: Eli Richmond, Lecille Gomez
    The Rehabinfo Network web site is funded by the US Dept. of Education's National Institute on Disability and Rehabilitation Research Grant #H133B980008, and the Dept. of Physical Medicine and Rehabilitation, UC Davis School of Medicine.
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